CiteScore values are based on citation counts in a range of four years (e.g. Drug development is notoriously capital intensive and, with more biotechs in existence than ever before, the industry requires a steady flow of investment to keep laboratories churning out new medicines. First published:October 23, 2020. Amgen, Biogen and Gilead remain independent, as do Regeneron and Vertex, two other early biotechs that have made it through a decades-long gauntlet of drug development and marketing as autonomous companies. Yet, more often than not, the agency's regulatory approval spurs a downward slide in the company's share price. The nuclear receptor–binding SET Domain (NSD) family protein is closely connected with many cancers. Interested in the genomes of algae? Biotech ended 2019 on a tear, buoyed by renewed dealmaking and unexpectedly positive trial results for several smaller companies. Photosynthesis in this leaf provides the majority of the carbohydrates needed for grain filling—so it ... Certain bacteria, known as plant-growth-promoting bacteria (PGPB), can improve plant health or protect them from pathogens and are used commercially to help crops. Surprising clinical successes played a role in the rebound, but more consequential was a spate of deals that emphasized biotech's upside. Last year left us with this piece of bombshell news: He Jiankui, the mastermind behind the CRISPR babies scandal, has been sentenced to three years in prison for violating Chinese laws on “scientific research and medical management.” Two of his colleagues also face prison for genetically engineering human embryos that eventually became the world’s first CRISPR’ d babies. Behind them are a slate of mid- to larger-size biotechs — now worth between roughly $10 and $20 billion — that are vying to become the sector's new standard bearers. The company successfully created organ-like tissue clusters capable of producing ovarian and testicular hormones. The question is whether it will continue. Weapons carved from human bone come from drowned land bridge between UK … Weedy Seadragon genomics reveal highly distinct populations, Genetic engineering without unwanted side effects helps fight parasites, Delicious and disease-free: scientists attempting new citrus varieties, An automated tool for assessing virus data quality, A one-stop shop for analyzing algal genomes, Light signal emitted during photosynthesis used to quickly screen crops, Chemical composition of wild potato relative contributes to its resistance to pathogen, Beyond changing DNA itself, mutagens also cause errors in gene transcription, Cellular exclusion of mitochondria protects cells from damage, A better reference genome for the rhesus macaque, Researchers decode the structure of the molecular complex that carries detoxifying enzymes in cells to the right place, Researcher boosts vegetable oil production in plant leaves, Scientists set a path for field trials of gene drive organisms, Study tracks elephant tusks from 16th century shipwreck, Jawless lamprey takes a bite out of cancer gene evolution, Controlling the nanoscale structure of membranes is key for clean water, researchers find, Stretching diamond for next-generation microelectronics, Light-responsive E. coli functional biofilms as scaffolds for hydroxyapatite mineralization, Well-preserved Ice Age woolly rhino found in Siberia, COVID-19 dominates annual list of banished words, terms, Scientists create a new phototoxic protein, SuperNova2, Whole genomes map pathways of chimpanzee and bonobo divergence, Eight genes enough to convert mouse stem cells into oocyte-like cells, From molecule to medicine via machine learning, How to stop infections caused by carbapenemase-producing bacteria, Proteins enable crop-infecting fungi to 'smell' food, Genome sequencing paves the way for more sustainable herring fishery, Scientists breed new rice variety with ion beam technology, Ancient DNA continues to rewrite corn's 9,000-year society-shaping history, New gene family of antimicrobial proteins discovered in German cockroaches, 'Boss' genes could save human hearts – and the reef, Finding the best crop traits just got easier, A genetic control of stem cell differentiation and organ maintenance by induction of fat metabolism, Researchers find why 'lab-made' proteins have unusually high temperature stability, How epigenetic switches control gene expression, Newly discovered toxin-antitoxin system abundant in one-cell organisms, High-speed model for the fight against SARS-CoV2, Using CRISPR, new technique makes it easy to map genetic networks, Embryonic development in a petri dish: 3-D cell culturing technique could replace mouse embryos, Heating proteins to understand how genes work, Organic meats found to have approximately the same greenhouse impact as regular meats, Designing Dirac vortex topological photonic crystal fibres, Observations shed more light on the atmosphere of white dwarf GD 424, ATLAS project finds 12 new species of sea creatures, Largest study of Asia's rivers unearths 800 years of paleoclimate patterns, Torpor: a neat survival trick once thought rare in Australian animals is actually widespread, The map of nuclear deformation takes the form of a mountain landscape, Scientists further improve accuracy of directional polarimetric camera, Researchers achieve sustained, high-fidelity quantum teleportation, Metasurface enabled quantum edge detection, New supercluster discovered by astronomers, Order and disorder in crystalline ice explained, Using economic data to create predictive models of anticipated antimicrobial resistance levels across countries, Scientists develop high-throughput mitochondria transfer device, Researchers publish review article on the physics of interacting particles, Big data kinase ohmics takes over drug discovery, Understanding COVID-19 infection and possible mutations, Tomatoes offer affordable source of Parkinson's disease drug, Algae superpowers could provide major boost to food security, Maize outpaces soybeans in fighting off fungal invasions, Researchers develop rapid genomics strategy to trace coronavirus, Meet the aquaculture industry's new maintenance bot, Researchers develop new multitasking microbe for simpler, cheaper and greener wastewater treatment, A single gene 'invented' hemoglobin several times, Electrons hop to it on twisted molecular wires, Switching DNA functions on and off with light. To further improve agricultural yields, it is helpful to ... Rhizodeposition of labile organic carbon is one of the main pathways linking above- and below-ground biota to affect soil carbon cycling. The late burst of activity brought 2019's M&A totals to decade highs, although Bristol-Myers' $74 billion buyout of Celgene and AbbVie's $63 billion acquisition of Allergan accounted for a large part of the overall sum. The expert panel's decidedly negative vote on aducanumab raised questions about the drug's future, as well as the credibility of the FDA. But did we really, though? NSF's mission is to advance the progress of science, a mission accomplished by funding proposals for research and education made by scientists, … Ned Pagliarulo That's down from 2018, but still strong compared to 2017 and 2016. All four areas are projected to surge in 2020 and beyond. "These re-focused companies are typically in 3 or 4 main therapeutic areas and require a steady stream of new products and development programs in those areas to sustain their long-term growth," wrote analysts at SVB Leerink. This ... UC Riverside scientists are betting an ancient solution will solve citrus growers' biggest problem by breeding new fruits with natural resistance to a deadly tree disease. … Should they stay independent, investors will monitor their product launches closely. As for the novel drug approvals, 53 drugs secured FDA nod in 2020 compared to 48 in 2019. However, their molecular mechanism remains unknown. "For many months in 2019, biotech traded as if it were a forgotten sector," wrote analysts at RBC Capital Markets in a year-end note to investors. Several smaller companies, among them GW Pharmaceuticals, Karyopharm and Acadia Pharmaceuticals, have beaten expectations with sales of their new drugs. "Investors are likely to be more cautious about an industry that will once again be a target for criticism and complaint during the run up to the 2020 elections," wrote analysts at SVB Leerink in a note to investors. BioMarin, long a rare disease drug specialist, achieved a major milestone when it submitted to the Food and Drug Administration valrox, its gene therapy for hemophilia A. Mergers and Acquisitions (M&A) The first three quarters of 2019 saw 242 mergers and acquisitions … Jan 11 – Jan 21, 2021, $1 billion buy of Achillion Pharmaceuticals, nearly $10 billion acquisition of The Medicines Company, secured approval of its sickle cell drug Oxbryta, 5 takeaways from the FDA's high-stakes meeting for Biogen's Alzheimer's drug, UK authorizes AstraZeneca, Oxford coronavirus vaccine, but questions linger, Merck signs $356M deal to supply US with experimental coronavirus drug, FDA scientists back safety, efficacy of Moderna's coronavirus vaccine, Novartis acquires a small biotech and its trio of brain drugs, Transforming the Pharma Supply Chain with Blockchain, What You Need to Know About Oncology's Research Boom, Inside the Rapidly Changing World of Gene Therapy, The World's Most Loathed Industry Gave Us a Vaccine in Record Time, Trump pardons Chris Collins, former congressman imprisoned for biotech insider trading scandal, European Healthcare Compliance Certificate Program, Overcoming Barriers to Treatment Adherence With Flexible Patient Services, Whitepaper: The Role of BioPhorum Extractables Data in the Effective Adoption of Single-Use Systems, Launch an Omnichannel Strategy That’s Scalable and Smart, Vertex teams up with Skyhawk, leaning on another biotech in bid to diversify, Changing identity, Agios to sell cancer drug business to Servier, Moderna's first FDA clearance brings the US a second coronavirus vaccine, MacroGenics wins FDA approval of breast cancer drug, A play-by-play of the FDA meeting on Moderna's coronavirus vaccine. This year, the biotech spent about $27 billion trying to become a leader in cancer research. UNIVERSITY PARK, Pa. — On June 12, the first Penn State BioTech Discovery Day brought together Penn State researchers, industry experts and venture investors for a day of technology reveals and networking opportunities focused on accelerating the transfer of Penn State’s top BioTech … Let’s look back at some of the top moments in the last 12 months. The free newsletter covering the top industry headlines, By Jacob Bell, Ned Pagliarulo and Ben Fidler •, By Ben Fidler, Jonathan Gardner and Ned Pagliarulo •, By signing up to receive our newsletter, you agree to our, • "Then, in what seemed like the blink of an eye, the entire group reversed course.". 6 hours 12 hours 1 day 3 days all. But, as recent setbacks have shown, reserachers and drugmakers still face major challenges. Stem cells can keep dividing infinitely and have the capacity to differentiate … Exposure to mutagens, or mutation-causing agents, can not only bring about changes in DNA but also appear to induce errors when genes are transcribed to make proteins, which may be an important factor in age-related diseases. With that in mind, here are five broader biotech trends to focus on this year. Strong performances from Democratic presidential candidates judged to be more critical of the industry could moderate investment, as was seen in 2016 when Hillary Clinton won the party's nomination. Is it mathematically possible that we could ... Charismatic, iconic and Instagram-friendly, the weedy seadragon is a favorite with divers and snorkellers. Discover announcements from companies in your industry. Taking their place at biotech's cutting edge are a range of more complex drug platforms, from new twists on monoclonal antibodies, to nucleic acid therapies and gene-based medicines. Biotechs were once defined by the type of drugs they developed — large molecule therapies produced from living cells. Still, there were 12 deals worth or surpassing $1 billion in value, three more than in 2018. Technology November 18, 2020 New Magnetic Spray Transforms Objects Into Insect-Scale Robots for Biomedical Applications An easy way to make millirobots by coating objects with a glue-like magnetic spray was developed in a joint research led by a scientist from City… Technology November 15, 2020 But what about lampreys? Amarin, having won a long-sought label expansion for its fish oil-derived pill Vascepa, is expected to capitalize on a large heart drug market. Its new discovery in the field of cancer immunotherapy produced mixed clinical … This site uses cookies to assist with navigation, analyse your use of our services, and provide content from third parties. Executives who spoke to BioPharma Dive said there's still work to be done. Biotechs spend years and hundreds of millions — if not billions — of dollars to bring a new medicines to the Food and Drug Administration. The rise of digital currency has massive ramifications for financial privacy. Shares in one sector-wide stock index had fallen sharply, erasing gains made earlier in the year. Through advances in sequencing technologies and computational approaches, more and more virus sequences are being recovered and identified from environmental samples (metagenomes). In a new study, researchers from Osaka University discovered a novel ... A large team of researchers from the U.S., Italy and Germany has developed a new and improved reference genomic assembly for the rhesus macaque. and Terms of Use. Venture capital carries biotechs through the early years, but companies quickly turn to initial and secondary share offerings to fuel their growth. Could COVID-19 have wiped out the Neandertals? Next week's J.P. Morgan Healthcare conference, always an industry barometer, will be an important gauge of how 2020 might shape up. The latest. The wreck was found in ... Mice, fruit flies and dogs are common creatures of laboratories across the country, valuable to researchers for their genetic proximity to humans. Date. Medical research advances and health news, The latest engineering, electronics and technology advances, The most comprehensive sci-tech news coverage on the web. ... Latest News /news/latest; ... Apple Is One of Barron's Top Stock Picks for the New Year. An international research team, led by Dr. Daniel Cohen of the Center for the Study of Human Polymorphisms in Paris, produces a rough map of all 23 pairs of human chromosomes. By RBC's count, nearly $33 billion was invested in biotech last year, about two-thirds of which came via secondaries. Victor Tangermann August 18th 2017 In recent years, metabolomics has arisen as a new tool to circumvent some of the bioassay-guided fractionation limitations and has shown its effectiveness in the discovery of new active compounds from marine sources (Einarsdottir et al., 2017; Naman et al., 2017; Stuart et al., 2020). Intel Had a Rough 2020… Get biopharma news like this in your inbox daily. The peculiar pattern is due to investor skepticism that small biotechs, having focused on R&D for so long, will be ill-suited for the task of actually selling their product. The Covid-19 pandemic caused huge disruption for European biotech in 2020, but the industry pulled through. Many discoveries about aliens in 2020 seemed to increase the prospect of extraterrestrial entities existing. Stem Cell Research. Partnerships between big pharmas and RNAi specialists Dicerna and Arrowhead Pharmaceuticals, as well as a nearly $10 billion acquisition of The Medicines Company by Novartis, suggest larger drugmakers are newly interested as well. Click here to sign in with Since antiquity, cultures around the world have been extracting vegetable oil from plants to use as food and fuel. Two smaller trade associations merge to form the Biotechnology Industry Organization, an international biotechnology advocacy group. Should it win approval in 2020, which is expected, BioMarin would cement its … Is forearm curvature in the 'Little Foot' Australopithecus natural or pathological? That tension will be on display next week at the closely watched J.P. Morgan Healthcare Conference, typically viewed as the "start" of the industry's new year. Now, after four-plus decades, these so-called biologics are somewhat old hat, the staple of drugmakers the industry over. Franklin Biotechnology Discovery Fund;A. In their paper published in the journal Science, the group describes using advanced ... Peroxisomes are essential, membrane-enclosed vesicles that occur in every cell. An arsenal of enzymes inside them breaks down harmful substances, thereby detoxifying the cells. Global Blood Therapeutics just secured approval of its sickle cell drug Oxbryta, adding a needed option for patients with the blood disease. Others, like Alexion Pharmaceuticals and BioMarin Pharmaceutical, have been multi-product companies for some time, but are in the midst of writing new corporate chapters. 12:01a. RBC estimates more than 200 public biotechs will need to raise money in 2020, about half of which lack sufficient funds to carry them through the entire year without tapping investors for more. Want to share a company announcement with your peers? Digital money. Subscribe to BioPharma Dive to get the must-read news & insights in your inbox. Follow BioMarin, long a rare disease drug specialist, achieved a major milestone when it submitted to the Food and Drug Administration valrox, its gene therapy for hemophilia A. Updated 10:34 AM ET, Mon June 22, 2020 The new circle was discovered near Stonehenge. The 10 Most Significant Scientific Discoveries Of the Year (So Far) It's proving to be one of the best years of the century, and we're barely halfway through. ... researchers from Osaka University discovered a novel ... Biotechnology Dec 21, 2020 ... 2020 powered by Science X Network. Acquisitions of Synthorx, ArQule, Audentes and Ra Pharmaceuticals came at premiums near or exceeding 100%, while Novartis' takeover of Medicines Co. was an unexpected boost to the RNAi field. This year will test whether others can succeed too. DUBLIN, March 16, 2020 /PRNewswire/ -- The "Global Discovery Stage Partnering Deal Terms & Agreements in Pharma and Biotech, 2014-2020" report has been added to ResearchAndMarkets.com's offering. 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